AOD-9604
Anti-Obesity Drug 9604 / hGH fragment 177-191
Fat-burning fragment of human growth hormone. Stimulates lipolysis without the anabolic or glucose effects of full GH. Completed Phase IIb human trials. Program paused vs GLP-1 competition.
Mechanism of action
Mimics the lipolytic region of GH via beta-3 adrenergic receptor stimulation and AMPK activation. Does NOT bind IGF-1 receptors so no muscle growth or blood glucose effects. Specifically targets visceral and subcutaneous fat metabolism through a different mechanism than GLP-1 drugs.
Effects in the body
AOD-9604 is GH's fat-burning function isolated and stripped of everything else. The anabolic and blood-sugar effects are absent making it potentially safer than full GH for metabolic research. Lower theoretical cancer concern than full GH due to absence of IGF-1R binding.
Pros & cons (from the literature)
- Targets fat metabolism without anabolic effects
- Does not elevate IGF-1 — lower cancer concern
- Completed Phase IIb human clinical trial
- Some oral bioavailability demonstrated
- Cartilage repair data in addition to fat metabolism
- Phase III trials paused — modest efficacy vs GLP-1 drugs
- Effects smaller than semaglutide or tirzepatide
- Gray market versions often mislabeled
- Limited large scale human evidence
- Mechanism different from but less proven than GLP-1 class
Protocol summary (from published research)
Dosing ranges reproduced from published research literature. Not a prescription, not medical advice.
FDA & regulatory status
Evidence base
Phase IIb RCT completed showing statistically significant fat reduction vs placebo. Multiple published pharmacokinetic studies. No Phase III completion.
Primary research sources
Peer-reviewed literature referenced throughout this profile is drawn from PubMed, Cell Metabolism, and clinical trial registries cited in the evidence base above.
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