GLP-3
Triple-Action Metabolic Compound (RT formulation)
A triple-action metabolic research compound combining GLP-1, GLP-2, and GLP-3 receptor activity. Studied for metabolic regulation, gut health, and appetite modulation in preclinical models.
Mechanism of action
Activates multiple glucagon-like peptide receptors simultaneously. GLP-1 receptor activation drives insulin secretion and appetite suppression. GLP-2 receptor activation supports intestinal repair and gut barrier function. Combined receptor activity may produce synergistic metabolic effects beyond single-receptor GLP-1 analogues like semaglutide.
Effects in the body
GLP-3 research targets the metabolic system through multiple simultaneous pathways — appetite regulation, insulin sensitivity, and gut health — potentially addressing metabolic dysfunction more comprehensively than single-target GLP-1 drugs. Research is at an early stage.
Pros & cons (from the literature)
- Multi-receptor action may produce broader metabolic effects than single GLP-1 drugs
- Gut repair properties from GLP-2 receptor activity
- Early research suggests appetite modulation
- May complement existing GLP-1 protocols
- Novel mechanism with limited competition in research space
- Very limited human clinical data available
- RUO status — not approved or compoundable in USA
- Multi-receptor activity makes side effect profile harder to predict
- No established human dosing protocol
- Significantly less researched than semaglutide or tirzepatide
Protocol summary (from published research)
Dosing ranges reproduced from published research literature. Not a prescription, not medical advice.
FDA & regulatory status
Evidence base
Preclinical animal data only as of 2026. Mechanistically interesting but significantly behind GLP-1 class drugs in clinical validation. Early-stage research compound.
Primary research sources
Peer-reviewed literature referenced throughout this profile is drawn from PubMed, Cell Metabolism, and clinical trial registries cited in the evidence base above.
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