Filter by category, search by name. Each profile is graded on a five-tier evidence scale.
ACTH(4-7)PGP
Russian-developed neuropeptide approved in Russia for stroke and TBI. Increases BDNF and NGF. Intranasal administration crosses blood-brain barrier effectively. Under FDA review for US Category 1 status.
PNB-0408 / N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
Estimated 7 million times more potent than BDNF at forming new synaptic connections in animal models. Developed at Washington State University for dementia research. Significant cancer concern via MET oncogene.
Vasoactive Intestinal Peptide
28-amino acid neuropeptide with remarkable anti-inflammatory lung-protective and cognitive properties. Significant research interest for Long COVID and chronic inflammatory response syndrome.
N-Acetyl Selank Amidate / Enhanced Selank / Selank analog
A modified version of Selank — N-acetylated and amidated at both ends of the peptide chain. These modifications are believed to increase resistance to enzymatic degradation and potentially extend duration of action compared to standard Selank. Carries the same anxiolytic and cognitive enhancement research interest as Selank but with significantly less published research behind the specific modification.
N-Acetyl Semax Amidate / Enhanced Semax / Semax analog
A modified version of Semax — N-acetylated and amidated — designed to improve enzymatic stability and potentially increase potency compared to standard Semax. Carries the same cognitive enhancement and neuroprotective research interest as Semax but with significantly less published research on the specific modification. Often described as a next-generation Semax.
Cibinetide / Innate Repair Receptor agonist / IRR agonist
A synthetic 11-amino acid peptide derived from erythropoietin (EPO) that selectively activates the Innate Repair Receptor (IRR) without stimulating red blood cell production. Studied for neuropathic pain, small fiber neuropathy, sarcoidosis, and metabolic syndrome. Has completed Phase II human trials. Genuinely interesting evidence profile for a non-hematopoietic EPO derivative.
EDR tripeptide / Glu-Asp-Arg / Pineal gland tripeptide
A synthetic tripeptide (Glu-Asp-Arg) derived from the pineal gland — part of the same Khavinson bioregulator family as Epitalon and Cartalax but targeting neuronal tissue specifically. Studied for neuroprotection, cognitive function, circadian rhythm regulation, and retinal protection. Russian clinical research from Dr. Khavinson's group spans several decades. English-language independent replication is limited.
